TABLE 7.
Reproductive outcomes of ARTs spermatozoa selected by IMSI.
| Sperm origin | Oocyte origin | Couples (n) | Sperm groups | Fertilization rate (%) | Cleavage% | Blastocyst (%) | Embryos transferred (n) | Clinical pregnancy (%) | Live birth rate/ET (%) | References |
| ≧3 millions of spermatozoa in the ejaculate, ≦1 million of motile after DGC, whatever sperm morphology | Younger than 39 years and FSH under of 9 UI/L | 458 | IMSI | 56 | ND | ND | ND | 31 | 27 | Leandri et al., 2013 |
| ICSI | 63 | 33 | 30 | |||||||
| Oligo-astheno-teratozoospermia | Patients | 66 | ICSI | 65 ± 21.1 | ND | ND | 64 | 6.3 | ND | Kim et al., 2014 |
| IMSI | 67.7 ± 19.9 | 66 | 27.3 | |||||||
| At least one sperm pathology | Infertile Women | 42 | IMSI | 51.4 | 95.3 | ND | ND | 41.3∗ | 34.7∗∗ | Shalom-Paz et al., 2015 |
| ICSI | 53.2 | 92 | 10.5 | 0 | ||||||
| Patients | Normo response (> 4 oocytes retrieved) | 324 | ICSI | 75.9 ± 18.9 | ND | 30.9 ± 28.1 | ND | 39,4 | ND | Setti et al., 2015 |
| IMSI | 72.3 ± 21.2 | 29.3 ± 25.7 | 34,1 | |||||||
| Poor response (< four oocytes retrieved) | 90 | ICSI | 79.8 ± 29.3 | ND | 9.8 ± 21.1 | ND | 11.8 | ND | ||
| IMSI | 53.9 ± 36.7 | 13.9 ± 33 | 22.2 | |||||||
| Couples with two previous ICSI failures | 216 | IMSI | 54 | ND | ND | 119 | 27 | 20 | Gatimel et al., 2016 | |
| ICSI | 61 | 86 | 28 | 19 | ||||||
| OAT/severe OAT (SOAT) or teratozoospermia | Patients | 57 | IMSI | 52∗∗ | ND | ND | ND | 68.5∗∗∗ | 62.4∗∗∗ | Goswami et al., 2018 |
| ICSI | 30 | 30.2 | 0 | |||||||
| Mild to severe oligo, astheno, and/or teratozoospermia | Donors | 848 | IMSI | 82 | 70 | 42 | 511 | 63,79 | Gaspard et al., 2018 | |
| ICSI | 72 | 69 | 40 | 923 | 69,33 | |||||
Values are expressed as % ± w/o, SEM, or SD. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.