Table 3.
Sensitivity of conventional malaria rapid diagnostic test by parasite density and age
| PCR-estimated parasite density, p/uL | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Any density | ≥ 100,000 | 100,000–10,000 | 10,000–5,000 | 5,000–1,000 | 1,000–500 | 500–200 | 200–100 | 100–10 | 10–1 | < 1 | |
| Age of all participants (years) | 36.0 (785/2,180) | 98.2 (54/55) | 96.8 (119/123) | 79.3 (23/29) | 86.7 (65/75) | 75.6 (31/41) | 76.5 (65/85) | 72.5 (79/109) | 41.6 (159/382) | 21.4 (135/631) | 8.5 (55/650) |
| < 5 | 49.3 (322/653) | 100 (37/37) | 98.6 (72/73) | 83.3 (10/12) | 85.2 (23/27) | 76.9 (10/13) | 88.6 (31/35) | 84.1 (37/44) | 44.2 (38/86) | 31.3 (51/163) | 8.0 (13/163) |
| 5–15 | 44.7 (342/765) | 100 (17/17) | 95.8 (46/48) | 92.3 (12/13) | 94.4 (34/36) | 85.0 (17/20) | 71.4 (25/35) | 82.1 (32/39) | 49.0 (72/147) | 27.3 (56/205) | 15.1 (31/205) |
| ≥ 15 | 15.9 (121/762) | 0 (0/1) | 50 (1/2) | 25 (1/4) | 66.7 (8/12) | 50 (4/8) | 60 (9/15) | 38.5 (10/26) | 32.9 (49/149) | 10.7 (28/263) | 3.9 (11/282) |
| P-value | < 0.001 | < 0.001 | 0.001 | 0.013 | 0.048 | 0.149 | 0.061 | < 0.001 | 0.017 | < 0.001 | < 0.001 |
| Age of asymptomatic household members (years) | 25.5 429/1,683) | 50.0 (1/2) | 76.5 (13/17) | 64.7 (11/17) | 82.4 (42/51) | 71.0 (22/31) | 66.7 (38/57) | 58.2 (39/67) | 35.9 (117/326) | 17.1 (93/545) | 9.3 (53/570) |
| < 5 | 23.2 (69/298) | NA | 75.0 (3/4) | 66.7 (4/6) | 70.0 (7/10) | 50.0 (2/4) | 63.6 (7/11) | 45.5 (5/11) | 19.2 (9/47) | 20.2 (20/99) | 11.3 (12/106) |
| 5–15 | 38.5 (240/624) | 1 (1/1) | 83.3 (10/12) | 85.7 (6/7) | 93.1 (27/29) | 84.2 (16/19) | 71.0 (22/31) | 80.0 (24/30) | 45.4 (59/130) | 24.6 (45/183) | 16.5 (30/182) |
| ≥ 15 | 15.8 (120/761) | 0 (0/1) | 0 (0/1) | 25.0 (1/4) | 66.7 (8/12) | 50.0 (4/8) | 60.0 (9/15) | 38.5 (10/26) | 32.9 (49/149) | 10.7 (28/263) | 3.9 (11/282) |
| P-value | < 0.001 | 0.157 | 0.168 | 0.127 | 0.068 | 0.124 | 0.740 | 0.005 | 0.003 | < 0.001 | < 0.001 |