Table 5.
Spearman’s correlation (ρ) between log-transformed parasite density and pro- and anti-inflammatory biomarkers and endothelial injury biomarker concentrations in Malawian children younger than 5 years with malaria
| Biomarker | Parasitemia (number of parasites/µL) | |
|---|---|---|
| Correlation (ρ) | P-value | |
| Pro-inflammatory | ||
| IL-6 (n = 28) | 0.58 | 0.001 |
| Tumor necrosis factor receptor-1 (n = 30) | 0.32 | 0.08 |
| IL-1β (n = 23) | 0.11 | 0.62 |
| Anti-inflammatory | ||
| IL-10 (n = 27) | 0.41 | 0.03 |
| Endothelial injury | ||
| von Willebrand factor antigen-2 (n = 29) | 0.08 | 0.68 |
| Intercellular adhesion molecule-1 (n = 32) | −0.05 | 0.78 |
| Angiopoietin-2 (n = 26) | 0.17 | 0.4 |
IL = interleukin.