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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: ALTEX. 2018 Jul 8;35(4):504–515. doi: 10.14573/altex.1803161

Fig. 5: Megalin-mediated cellular uptake and loss of DBP-bound 25OHD3 in the PT-MPS.

Fig. 5:

The rate of loss of 25OHD3 from the perfusion medium was observed to be roughly proportional to the 25OHD3 input concentrations across the measured range of input concentrations tested. RAP significantly reduced the estimated intrinsic clearance, reflected in the slope of the linear regression line, of 25OHD3 from the luminal perfusion medium.