Tab. 1: Donor-specific effects of RAP on the intrinsic clearances of 24,25(OH))₂D₃ formation and 25OHD₃ loss.

Treatment with the megalin inhibitor (RAP) significantly reduced the intrinsic clearance for 25OHD₃ loss (CL_int,25OHD3) to PTECs cultured in the PT-MPS but had no significant effect on the intrinsic clearance of 24,25(OH)₂D₃ formation (CL_{int,24,25(OH)2D3}).

	CLint,24,25(OH)2D3 (μl/h)			CLint,25OHD3 (μl/h)
Donor No.	No RAP	RAP	Fold-change CLint	No RAP	RAP	Fold-change CLint
1	0.015	0.021	1.4 ↑	1.7	0.42	4.0 ↓
2	0.00029	0.00037	1.3 ↑	4.0	1.1	3.6 ↓
3	0.038	0.036	1.1 ↓	2.5	3.2	1.3 ↑
4	0.0052	0.0021	2.5 ↓	2.6	0.78	3.3 ↓
5	0.056	0.052	1.1 ↓	2.8	1.3	2.2 ↓
Mean†	0.023	0.022	1.1 ↓	2.7	1.4	*2.4 ↓
SD†	0.024	0.022	1.6	0.83	1.1	2.0

^†Geometric mean and geometric standard deviation calculated for “fold-change” (ratio) parameters.

^*, p < 0.05.