Figure 2.

Autophagy and major features of asthma. Environment/allergen exposure initiates ROS generation in airway epithelial cells, which serve as “signaling molecules” modulating the process of autophagic cycle through activating signaling molecules and autophagy pathways, thereby leading to the major phenotypic changes of asthma, including airway inflammation, airway remodeling, and airway hyper-responsiveness.