Table 5.
Parameter | Cmax (ng.mL−1) | AUC(0- ∞) (ng.h.mL−1) | Half-Life (h) | Clearance (L.h−1) | Volume of Distribution (L) |
---|---|---|---|---|---|
Mean | 357 | 228 | 3.73 | 43.5 | 171 |
SD | 149 | 18.9 | 0.519 | 3.21 | 26.0 |
Geometric mean | 330 | 227 | 3.70 | 43.4 | 169 |
Median | 344 | 230 | 3.63 | 42.7 | 177 |
Range | 214–538 | 205–252 | 3.17–4.58 | 39.9–48.9 | 122–200 |
Abbreviations: Cmax, peak plasma concentration; AUC(0- ∞), area under the curve from time zero to infinity.