. 2019 Nov 29;10:1225. doi: 10.3389/fneur.2019.01225

Table 1.

Summary of histological measurements for each group.

	Sham	Vehicle	hUC-MSCs	hUC-MSC-EVs
Iba1⁺ cells/mm³
Gray matter
2 mm	12,276 ± 1,234	39,410 ± 5,922^###	29,419 ± 4,819^***, ^###	27,955 ± 4,393^***, ^###
3 mm	13,112 ± 2,521	31,653 ± 3,327^###	23,652 ± 1,285^***, ^###	23,108 ± 2,957 ^***, ^###
White matter
2 mm	13,078 ± 2,399	29,772 ± 5,941^###	20,788 ± 5,005^**, ^###	19,518 ± 3,372^***, ^###
3 mm	12,830 ± 1,386	21,549 ± 4,476^###	15,578 ± 2,850^**, ^###	16,964 ± 2,892^*, ^###
Freq. Iba1⁺ cells
Gray matter
<150 μm²	0.56 ± 0.04	0.75 ± 0.04^###	0.76 ± 0.05^{n.s., ###}	0.75 ± 0.04^{n.s., ###}
≥150 μm²	0.43 ± 0.04	0.25 ± 0.04^###	0.24 ± 0.05^{n.s., ###}	0.25 ± 0.04^{n.s., ###}
White matter
<150 μm²	0.56 ± 0.04	0.75 ± 0.03^###	0.76 ± 0.04^{n.s., ###}	0.75 ± 0.04^{n.s., ###}
≥150 μm²	0.43 ± 0.04	0.25 ± 0.04^###	0.24 ± 0.04^{n.s., ###}	0.24 ± 0.04^{n.s., ###}
CD3⁺cells/mm³	46.8 ± 7.4	294.8 ± 82.1^###	285.9 ± 62.6^{n.s., ###}	220.5 ± 57.2^{n.s., ###}
GFAP⁺ cells/mm³	17,178 ± 2,243	19,908 ± 5,212^n.s.	20,228 ± 5,613^{n.s., n.s.}	20,541 ± 3,521^{n.s., n.s.}
% GFAP⁺ Area	2.2 ± 0.7	14.4 ± 8.6^###	5.5 ± 3.2^{**, n.s.}	5.7 ± 2.5^{**, n.s.}
Total Collagen I area (μm²)	29,011 ± 15,903	2,203,763 ± 936,900^###	1,503,775 ± 853,435^{n.s., ##}	959,715 ± 560,646 ^{**, n.s.}
Spared tissue volume (mm³)	38.3 ± 3.05	21.2 ± 2.2^###	20.8 ± 3.7^{n.s., ###}	21.6 ± 3.0^{n.s., ###}
Number ChAT⁺ cells	52.3 ± 5.8	32.4 ± 6.4^{#, n.s.}	36.4 ± 11.1^{n.s., n.s.}	38.2 ± 9.8^{n.s., n.s.}
Total CSPG-NG2 area (μm²)	538,731 ± 43,789	3,690,575 ± 527,086^###	2,993,413 ± 637,420^{###, n.s.}	2,735,803 ± 682,481^{###, *}

Statistical significant differences to the sham group are marked with

p ≤ 0.05;

^##

p ≤ 0.01; and

^###

p ≤ 0.001. Statistical significant to differences to the vehicle are marked with

p ≤ 0.05;

^**

p ≤ 0.01; and

^***

p ≤ 0.001. Non-significant differences are marked with n.s.