Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Nov 29;9:1293. doi: 10.3389/fonc.2019.01293

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Tomasetti, Gaetani, Monaco, Neuzil and Santarelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Model of PARP1-mediated control of chromatin structure in the regulation of miRNA expression. PARP1 promotes the interaction of UHRF1 with DNMT1 in regulating miRNA expression independently of DNA methylation. In addition, PARP1 activation facilitates the demethylation of DNA by the recruitment of TET1 and by the exclusion of DNMT1. Inhibition of PARP1 reduces the interaction of the UHRF1-DNMT1 complex that regulates chromatin condensation and enhances transcription.