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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2019 May 29;378:114603. doi: 10.1016/j.taap.2019.114603

Fig. 2.

Fig. 2.

miR-143 is involved in inhibiting IL-6 and other related signaling molecules. (A)miR-143 overexpression decreased IL-6 protein (left) and IL-6 mRNA (right) expression. (B)miR-143 overexpression greatly decreased protein expression of IRS1 and p70S6K1, whereas an anti-miR-143 inhibitor induced expression of IRS1 and p70S6K1. Data are presented as mean ± SD from 3 replicates. * indicates significant difference at P < .05, ** indicates significant difference at P < .01, * and ** indicate P value when miR-143 is compared with miR-NC; # indicates significant difference at P < .05, ## indicates significant difference at P < .01, # and ## indicate P value when an anti-miR-143 inhibitor is compared with a miR-NC inhibitor.