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. Author manuscript; available in PMC: 2020 May 20.
Published in final edited form as: Nature. 2019 Nov 20;576(7785):112–120. doi: 10.1038/s41586-019-1775-1

Extended Data Fig. 5 ∣. Clonal structure evolution over time.

Extended Data Fig. 5 ∣

a. The minimum cancer cell fraction of the most persistent (shared between initial and recurrence) PyClone cluster. b. Comparison of PyClone clusters ranked by CCF in matched initial and recurrent tumors, as Fig. 2b but separated by subtype. c-d. Examples of cluster CCF dynamics over time in three separate samples, including (c) two multi-timepoint samples (d) and one multi-sector sample. These additional data are available in the GLASS resource, but only two time-separated samples were used throughput the manuscript to ensure clarity.