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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: Br J Haematol. 2019 Feb 6;185(6):1021–1042. doi: 10.1111/bjh.15764

Fig 10.

Fig 10.

Distrubtion of TNFRSF14 mutations on protein and exon level in paediatric type follicular lymphoma. (A) TNFRSF14 protein with its different domains and the cysteine repeats (TNFR-Cys 1–3) above. Below, localization of exons is indicated by dashed lines with position of splice site mutations. Domains of the protein are represented according to the Uniprot database (www.uniprot.org). Exact positions of each TNFRSF14 mutation found in 21 cases of paediatric type follicular lymphoma (PTFL) are given. (B) Coverage representation for TNFRSF14 exons 1–8 of all PTFL and reactive hyperplasia (RH) samples included in the study. The spacing of the scale on the y-axis is proportional to the logarithm of the number. (C) Exemplary view of the Integrative Genomics Viewer (IGV) showing the mutation p.M1_97del of PTFL11. Republished with permission of the American Society of Hematology, from: Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene., Schmidt, J., Gong, S., Marafioti, T., Mankel, B., Gonzalez-Farre, B., Balague, O., Mozos, A., Cabeca-das, J., van der Walt, J., Hoehn, D., Rosenwald, A., Ott, G., Dojcinov, S., Egan, C., Nadeu, F., Ramis-Zaldivar, J.E., Clot, G., Barcena, C., Perez-Alonso, V., Endris, V., Penzel, R., Lome-Maldonado, C., Bonzheim, I., Fend, F., Campo, E., Jaffe, E.S., Salaverria, I. & Quintanilla-Martinez, L., Blood, 128, 1101–1111, copyright 2016; permission conveyed through Copyright Clearance Center, Inc.