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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: Br J Haematol. 2019 Feb 6;185(6):1021–1042. doi: 10.1111/bjh.15764

Fig 2.

Fig 2.

(A) Cumulative incidence of chronic health conditions among 10 397 adult survivors of paediatric cancer, according to the original diagnosis and the severity of the later condition. Among the survivors of various types of childhood cancer, the severity of subsequent health conditions was scored according to the Common Terminology Criteria for Adverse Events (version 3) as either mild (grade 1), moderate (grade 2), severe (grade 3), life-threatening or disabling (grade 4), or fatal (grade 5). For the total survivor cohort, the curves showing the cumulative incidence of the two outcomes by grade are truncated at 28 years, even though the text provides data up to 30 years after the original cancer diagnosis. This was done for consistency with the panels showing data for groups of patients with certain types of cancer, in which smaller samples yielded data that were not as robust at 30 years as they were at 28 years. NHL, non-Hodgkin lymphoma. From New England Journal of Medicine, Oeffinger, K.C., Mertens, A.C., Sklar, C.A., Kawashima, T., Hudson, M.M., Meadows, A.T., Friedman, D.L., Marina, N., Hobbie, W., Kadan-Lottick, N.S., Schwartz, C.L., Leisenring, W., Robison, L.L. & Childhood Cancer Survivor, S. Chronic health conditions in adult survivors of childhood cancer. 355, 1572–1582. Copyright ©2006 Massachusetts Medical Society. Modified with permission from Massachusetts Medical Society. (B) and (C) Cumulative incidence (B) and burden (C) of all (grade 1–5) chronic health conditions in St Jude lifetime cohort study survivors of childhood cancer and in community controls. Reprinted from The Lancet, 390, Bhakta, N., Liu, Q., Ness, K.K., Baassiri, M., Eissa, H., Yeo, F., Chemaitilly, W., Ehrhardt, M.J., Bass, J., Bishop, M.W., Shelton, K., Lu, L., Huang, S., Li, Z., Caron, E., Lanctot, J., Howell, C., Folse, T., Joshi, V., Green, D.M., Mulrooney, D.A., Armstrong, G.T., Krull, K.R., Brinkman, T.M., Khan, R.B., Srivastava, D.K., Hudson, M.M., Yasui, Y. & Robison, L.L., The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE), 2569–2582. Copyright 2017, with permission from Elsevier.