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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: Br J Haematol. 2019 Feb 6;185(6):1021–1042. doi: 10.1111/bjh.15764

Fig 5.

Fig 5.

PCNSL and PTL harbour frequent 9p24.1 PD-L1/PD-L2 copy number alterations and infrequent translocations. (A) Genomic Identification of Significant Targets in Cancer (GISTIC)-defined copy number alterations (CNAs) in large B-cell lymphoma subtypes. GISTIC-defined recurrent CNAs (amplification in red) in 180 primary DLBCLs14 are compared with those in 11 primary mediastinal B-cell lymphomas (left panel) and 28 PCNSLs/PTLs (right panel) in mirror plots. Chromosome position is on the y-axis, and significance is on the x-axis. The green line denotes q value of 0 25. (B) Genetic alterations of CD274 (PD-L1) and PDCD1LG2 (PD-L2) in PTL and PCNSL. CNs of PD-L1 in 50 PCSNL cases (42 EBV- and 8 EBV1) from the extension cohort. CNs of CD274 (PD-L1) in 43 PTL cases from the extension cohort. Normals include 5 tonsils and 5 reactive lymph nodes. The upper 95% confidence interval of the normals was used as a threshold for CN gain in the PTLs. Indicated cHL cell lines with known CD274 (PD-L1) copy gain were used as controls. Cases with copy gain are highlighted in red. Error bars reflect standard deviation. The scale bar represents 100 mm. CD274/PD-L1: programmed death ligand 1 gene; cHL, classical Hodgkin lymphoma; CN, copy number; DLBCL, diffuse large B-cell lymphoma; EBV, Epstein-Barr virus; PCNSL, primary central nervous system lymphoma; PDCD1LG2/PD-L2, programmed death ligand 2 gene; PTL, primary testicular lymphoma; TL, testicular lymphoma. Republished with permission of the American Society of Hematology, from: Targetable genetic features of primary testicular and primary central nervous system lymphomas., Chapuy, B., Roemer, M.G., Stewart, C., Tan, Y., Abo, R.P., Zhang, L., Dunford, A.J., Meredith, D.M., Thorner, A.R., Jordanova, E.S., Liu, G., Feuerhake, F., Ducar, M.D., Illerhaus, G., Gusenleitner, D., Linden, E.A., Sun, H.H., Homer, H., Aono, M., Pinkus, G.S., Ligon, A.H., Ligon, K.L., Ferry, J.A., Freeman, G.J., van Hummelen, P., Golub, T.R., Getz, G., Rodig, S.J., de Jong, D., Monti, S. & Shipp, M.A., Blood, 127, 869–881, copyright 2016; permission conveyed through Copyright Clearance Center, Inc.