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Percentage of huCD45+ cells in peripheral blood over time (A), and event-free survival curves (B) for ALL-19 engrafted NOD/SCID mice treated with alisertib at 10.4 mg/kg twice daily for 7 days (Schedule A, red), or twice daily for 5 days repeated for 3 weeks (Schedule B, blue) in relation to vehicle-treated controls (dotted line).
