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. Author manuscript; available in PMC: 2019 Dec 6.
Published in final edited form as: Nucl Receptor Res. 2019 Nov 20;6:101447. doi: 10.32527/2019/101447

Figure 1. Phase 0 response to xenobiotics is activation of a transcriptional response by xenobiotic responsive transcription factors.

Figure 1.

Phase I-III detoxication is well documented and relatively well defined as oxidative metabolism, conjugation, and transport, respectively. Phase 0 xenobiotic response is defined as the transcriptional response of and initial acclimation of the cell to xenobiotics leading to increased phase I-III detoxication through gene regulation. R/TF = receptor/transcription factor.