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. 2019 Nov 22;15(11):e1008128. doi: 10.1371/journal.ppat.1008128

Fig 8. Cell culture validated PI-rTSP (rAamIGFBP-rP1, rAamIGFBP-rP6S, and rAamIGFBP-rPL6) and AI-rTSP (rAAS27 and rAAS41) are functional in vivo.

Fig 8

Line diagram showing increase in paw swelling in mice injected with high dose (25 μg: A, B) and low dose (10 μg: C, D) of cocktail or individual rAamIGFBP-rP1, rAamIGFBP-rP6L, and rAamIGFBP-rP6S or rAAS27 and rAAS41. Data is represented as mean of three biological replicates ± SEM. Filled red squares = carrageenan injected, blue hexagon = normal saline, green filled hexagon, triangle = rAamIGBP-rP1 injected groups, light blue circle = rAamIGBP-rP6L, Black star = rAamIGBP-rP6S, Open circle = PI-rTSP cocktail, Open square = PI-rTSPs + AI-rTSPs cocktail (*) = p ≤ 0.05, (**) = p ≤ 0.01, (***) = p ≤ 0.001, (****) = p ≤ 0.0001 indicating statistically significant difference between normal saline injected group and treatments groups. No asterisks indicated represent non-statistical significance. Arrow (↑) indicate increase in paw volumes compared to normal saline control and arrow (↓) indicate decrease in paw volumes compared to PI-rTSPs injected paws.