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. 2019 Nov 22;15(11):e1008128. doi: 10.1371/journal.ppat.1008128

Fig 10. A. americanum tick PI-rTSP induce expression of pro-inflammation cytokines in vivo, AI-rTSPs suppresses.

Fig 10

Relative transcript abundance of cytokines in paws that were treated with low dose individual PI-rTSPs (A, B, C, and D) or with cocktail PI-rTSP or Carageenan followed by individual or cocktail AI-rTSP (E, F, G, and H). Fig 10I, 10J, 10K and 10L = paws that were injected with high dose individual PI-rTSPs; and Fig 10M, 10N, 10O and 10P = were injected with high dose PI-rTSPs and AI-rTSP cocktail. Data is reported as Mean (M) of two biological replicates ± SEM. Asterisks (*) = p ≤ 0.05, (**) = p ≤ 0.01, (***) = p ≤ 0.001, (****) = p ≤ 0.0001 indicating statistically significant difference between normal saline injected group and treatments groups. No asterisks mean non-significance. Arrow (↓) indicate decrease in cytokine transcript abundance compared to normal saline controls.