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. 2019 Dec 6;14(12):e0225137. doi: 10.1371/journal.pone.0225137

Table 3. The functions associated with hematological system development: Top 1000 FDR corrected DEGS from whole blood when frozen vs. cold conditions are compared using BH p-value (Benjamin-Hochberg corrected p-value) settings in IPA.

Diseases or Functions Annotation p-Value # Molecules
Quantity of mononuclear leukocytes 5.82E-14 85
Quantity of lymphocytes 9.93E-13 80
Quantity of blood cells 4.24E-12 102
Quantity of leukocytes 9.47E-12 93
Quantity of T lymphocytes 2.85E-09 58
Quantity of hematopoietic progenitor cells 6.46E-09 50
Quantity of B lymphocytes 7.11E-08 40
Cell movement of natural killer cells 2.80E-07 14
Morphology of lymphoid tissue 3.79E-07 53
Lymphopoiesis 4.44E-07 62
Abnormal morphology of lymphoid organ 6.91E-07 39
Cell movement of leukocytes 9.72E-07 71
Recruitment of natural killer cells 9.82E-07 7
Cell movement of lymphocytes 1.09E-06 42
Function of T lymphocytes 1.18E-06 29
Accumulation of blood cells 1.20E-06 32
Formation of lymphoid tissue 1.33E-06 37
Morphology of lymphoid organ 1.53E-06 48
Quantity of thymocytes 1.55E-06 27
Differentiation of mononuclear leukocytes 1.98E-06 63
Leukopoiesis 3.67E-06 69
Cell movement of mononuclear leukocytes 4.43E-06 46
Homing of lymphocytes 4.63E-06 20
NK cell migration 4.69E-06 10
Differentiation of B lymphocytes 5.52E-06 26
Accumulation of leukocytes 6.14E-06 29
Extravasation of phagocytes 7.08E-06 8
Migration of mononuclear leukocytes 7.10E-06 38
Lymphocyte migration 7.32E-06 36
Function of lymphocytes 7.55E-06 31
Chemotaxis of lymphocytes 1.08E-05 17
Morphology of spleen 1.18E-05 37
Abnormal morphology of thymus gland 1.22E-05 18
Quantity of monocytes 1.23E-05 16
Homing of leukocytes 1.35E-05 37
Abnormal morphology of germinal center 1.39E-05 11
Activation of lymphocytes 1.56E-05 41
Recruitment of T lymphocytes 1.84E-05 12
Chemotaxis of leukocytes 2.25E-05 35
Activation of mononuclear leukocytes 2.43E-05 42
T cell homeostasis 2.61E-05 48
Recruitment of lymphocytes 2.83E-05 14
Extravasation of leukocytes 3.45E-05 9
Formation of lymphoid organ 3.81E-05 28
Proliferation of mononuclear leukocytes 4.44E-05 60
Accumulation of mononuclear leukocytes 4.89E-05 18
Morphology of thymus gland 5.17E-05 21
Proliferation of lymphocytes 5.54E-05 59
Extravasation of neutrophils 6.73E-05 6
Activation of blood cells 6.92E-05 58
Formation of lymph node 7.62E-05 14
Proliferation of immune cells 7.95E-05 61
Function of granulocytes 8.19E-05 8
Homing of mononuclear leukocytes 8.40E-05 22
Chemotaxis of natural killer cells 8.60E-05 7
Quantity of regulatory T lymphocytes 9.13E-05 15
Abnormal morphology of spleen 9.44E-05 26
Cell movement of T lymphocytes 9.67E-05 24
T cell migration 1.21E-04 26
T cell development 1.25E-04 45
Recruitment of leukocytes 1.45E-04 30
Development of hematopoietic system 1.51E-04 30
Morphology of lymph follicle 1.62E-04 15
Accumulation of lymphocytes 1.63E-04 16
Quantity of short-term hematopoietic stem cells 1.73E-04 3
Delay in accumulation of leukocytes 1.73E-04 3
Function of myeloid cells 2.03E-04 20
Recruitment of mononuclear leukocytes 2.37E-04 15
Activation of CD8+ T lymphocyte 2.45E-04 6
Chemotaxis of mononuclear leukocytes 2.65E-04 19
Emigration of mononuclear leukocytes 2.79E-04 4
Abnormal morphology of enlarged spleen 3.31E-04 17
Activation of T lymphocytes 3.43E-04 30
Cell proliferation of T lymphocytes 3.47E-04 47
Activation of leukocytes 3.65E-04 52
Quantity of CD4+ T-lymphocytes 3.99E-04 17
Migration of follicular B lymphocytes 4.26E-04 4
Egression of leukocytes 4.27E-04 5
Maturation of leukocytes 4.35E-04 21
Cell movement of B lymphocytes 5.33E-04 12
Development of bone marrow 6.03E-04 20
Accumulation of myeloid cells 6.15E-04 18
Quantity of long-term hematopoietic stem cells 6.20E-04 4
Accumulation of blood platelets 6.20E-04 4
Formation of thymus gland 6.82E-04 17
Response of lymphocytes 7.17E-04 19
Differentiation of T lymphocytes 7.98E-04 32
Osteoclastogenesis of bone marrow 8.40E-04 7
Egression of lymphocytes 1.19E-03 4
Cell movement of marginal-zone B lymphocytes 1.19E-03 4
Proliferation of B lymphocytes 1.24E-03 25
Circulation of blood 1.32E-03 9
Accumulation of phagocytes 1.39E-03 15
Deposition of blood platelets 1.40E-03 3
Differentiation of colony-forming erythroid cells 1.40E-03 3
Size of lymphoid organ 1.44E-03 10
Cell movement of cytotoxic T cells 1.57E-03 4
Abnormal quantity of leukocytes 1.99E-03 10
Homing of T lymphocytes 2.02E-03 12
Differentiation of B-1 lymphocytes 2.04E-03 4
Formation of germinal center 2.05E-03 8
Osteoclastogenesis of leukocytes 2.05E-03 7
Trafficking of macrophages 2.18E-03 3
Recruitment of blood platelets 2.18E-03 3
Activation of cytotoxic T cells 2.30E-03 7
Formation of spleen 2.33E-03 10
Homing of B lymphocytes 2.35E-03 6
Binding of professional phagocytic cells 2.38E-03 18
Quantity of myeloid cells 2.57E-03 37
Development of monocyte-derived macrophages 2.59E-03 4
Osteoclastogenesis of macrophages 2.68E-03 6
Aggregation of blood platelets 2.72E-03 18
Expansion of lymphocytes 2.87E-03 16
T cell response 3.12E-03 15
Expansion of leukocytes 3.14E-03 17
Lack of white pulp 3.19E-03 3
Proliferation of plasma cells 3.19E-03 3
Accumulation of granulocytes 3.19E-03 11
Activation of naive T lymphocytes 3.24E-03 4
Migration of thymocytes 3.24E-03 4
Osteoclastogenesis of bone marrow-derived macrophages 3.25E-03 5
Quantity of double-positive thymocyte 3.41E-03 11
Recruitment of macrophages 3.41E-03 11
Maturation of antigen presenting cells 3.55E-03 12
Quantity of follicular B lymphocytes 3.55E-03 12
Morphology of lymph node 3.62E-03 15
Delay in accumulation of T lymphocytes 3.69E-03 2