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. 2019 Dec 6;14(12):e0226145. doi: 10.1371/journal.pone.0226145

Fig 2. Effects of Gö6976 on the development and progression of CIA.

Fig 2

HLA-DR1 mice were immunized with bovine CII and treated daily with vehicle (n = 10) or Gö6976 (n = 10) for 34 days starting at the day of CII immunization. Mice were observed daily and development of arthritis was assessed. (A) Incidence of arthritis. (B) Mean arthritis severity. Data represent the mean ± SD. *, p < 0.05; **, p < 0.005. (C) The % of arthritic paws. (D) Mean number of arthritic paws in a mouse. Data represent the mean ± SD. *, p < 0.05; **, p < 0.005. (E) Arthritis severity score in an arthritic mouse. Data represent the mean ± SD. *, p < 0.05; **, p < 0.005. (F) Number of arthritic paws in an arthritic mouse. Data represent the mean ± SD. *, p < 0.05; **, p < 0.005. Experiments were repeated four times with similar results.