Table 1.

Univariate and Multivariate Analysis for OS and Tumor Recurrence

Characteristic	OS				Tumor Recurrence
	Univariate		Multivariate		Univariate		Multivariate
P Value	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)
Age ≥60	0.163	1.39 (0.88–2.20)			0.326	1.26 (0.79–.02)
Sex (female)	0.458	0.84 (0.52–1.34)			0.385	0.81 (0.50–.31)
PBD	0.195	1.44 (0.83–2.48)			0.089	1.60 (0.93–2.75)
Bismuth type (III-IV vs I-II)	0.185	1.50 (0.82–2.74)			0.253	1.44 (0.77–2.68)
Bilirubin (>3mg/dL)	0.005	2.26 (1.28–4.01)			0.002	2.55 (1.41–4.63)
Bilirubin (>6mg/dL)	0.005	2.13 (1.26–3.61)			0.011	2.00 (1.17–3.41)
Bilirubin (>12mg/dL)	<0.001	3.55 (2.04–~6.18)	0.012	2.34 (1.21–4.54)	<0.001	3.29 (1.89–5.71)	0.029	2.07 (1.08–3.97)
CEA ≥4.7 U/mL	0.354	1.35 (0.71–2.57)			0.686	1.14 (0.59–2.20)
CA19-9≥39U/mL	0.261	1.60 (0.70–3.65)			0.333	1.54 (0.64–3.71)
CL (types III and IV)	0.709	1.15 (0.55–2.38)			0.646	1.19 (0.57–2.46)
Liver resection (types III and IV)	0.049	0.45 (0.20–1.00)			0.024	0.40 (0.18–0.88)
Positive tumor margin	<0.001	3.57 (2.20–5.80)	0.003	2.79 (1.42–5.49)	<0.001	3.29 (2.01–5.40)	<0.001	3.52 (1.74–7.14)
Tumor size ≥2 cm	0.330	1.36 (0.73–2.55)			0.249	1.45 (0.77–2.71)
Differentiation
Moderate vs well	0.121	1.63 (0.88–3.02)			0.206	1.49 (0.80–2.75)
Poor vs well	0.143	2.03 (0.79–5.26)			0.488	1.45 (0.51–4.12)
Vascular invasion	0.032	2.35 (1.08–5.16)			0.955	1.03 (0.32–3.29)
Perineural invasion	0.015	1.78 (1.12–2.83)	0.008	2.42 (1.26–4.65)	0.017	1.78 (1.11–2.87)	0.001	3.31 (1.68–6.55)
Lymph node metastasis	<0.001	2.64 (1.65~–4.22)			<0.001	2.55 (1.57–4.12)
TNM stage (III–IV vs I–II)	<0.001	3.85 (2.17–6.85)	0.013	4.67 (1.38–15.87)	<0.001	3.49 (1.94–6.31)	0.017	4.37 (1.30–14.71)