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. 2019 Dec 6;10:5609. doi: 10.1038/s41467-019-13521-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Experimental design. Adult-born neurons aged 8 days at the beginning of the first enrichment were transduced with a lentivirus expressing halorhodopsin (Halo) or with an empty virus (Cont). Light stimulation was performed during the test trial of the habituation/dishabituation task. b–d Behavioral results. b The learned discrimination of +lim/−lim is abolished by light stimulation in the Halo group (n = 13), but not in the Control group (n = 12). c Discrimination between dec/dodec is not altered by light stimulation (Cont n = 13; Halo n = 14). d Discrimination between a dissimilar odorant pair +lim/ +carvone is not altered by light-triggered inhibition of adult-born neurons (Cont n = 9; Halo n = 14). t-tests *p < 0.05, **p < 0.01, ***p < 0.001 (for difference between Hab4 and Test in b–d). e The density of EYFP-positive transduced cells in the OB is similar between Control (n = 9) and Halo (n = 7) animals. f Percentage of EYFP/Zif268-positive cells after light-triggered inhibition is decreased in Halo (n = 7) compared to Control (n = 8). t-test *p < 0.05 (for difference between Halo and Control groups in f). Data are represented as data points and mean ± sem. Source data are provided as a Source Data file.