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. 2019 Dec 6;9:18545. doi: 10.1038/s41598-019-53867-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Relaxin up-regulates Nav1.5 in LV cardiomyocytes. (A) Rat ventricular myocytes treated with increasing concentrations of RLX were fixed and labeled with Nav1.5 Ab. The data show that Nav1.5 fluorescence visibly increases with RLX treatment. (B) Dose-response of the ratio of Nav1.5 to phalloidin fluorescence (used for normalization purposes). EC₅₀~1.3 nM, (n = 6 wells/data point, P < 0.01). (C,D) RLX significantly increased Nav1.5 expression in isolated myocytes compared to control (n = 10–12 cells/group; 3 replicate experiments). 600x magnification, scale bars (25 µm) apply to all panels.