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. 2019 Dec 6;9:18518. doi: 10.1038/s41598-019-55084-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity pathway network analysis of the genes targeted by the 4 differentially-expressed miRNAs and cMET immunohistochemistry of primary breast cancer that did not recur (BCNR), primary BCR and breast cancer brain metastasis (BCBM). (A) IPA of the 147 genes targeted enrichment analysis linked them to 4 major networks (ID1-4), the top identified network (ID 1) is illustrated with the highest score and focus molecules. MET (cMET) oncogene was one of the genes in this network (B) cMET IHC using the H-score as a semi-quantitative measure for the t-test analysis identified a significant overexpression of cMET in BCRs and in BCBMs (p < 0.0001: BCNR vs BCR and p = 0.0008: BCNR vs BCBM). (C) Representative examples stained for cMET of 2 primary breast cancer cases without recurrence (BCNR1 and BCNR2) and 2 primary BCR with their matched brain metastasis (BCR1 and BM1, BCR2 and BM2).