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. 2019 Dec 6;10:5574. doi: 10.1038/s41467-019-13132-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Mathematical modeling of TCX2 network predicts timing of cell division. a TCX2 first-neighbor TF networks predicted using RTP-STAR on the stem cell time course for 4 day (4D) to 4 days 8 h (4D 8H) (top), 4D 8H to 4D 16H (middle), and 4D 16H to 5D (bottom). Networks are separated based on the cell type the genes are expressed in: QC (yellow), CEI (blue), CSCs (purple), Epi/LRC (green), Xyl (orange). Arrows represent predicted activation, bars inferred repression, and circles no inferred sign. b (left) Representative image of TCX2:TCX2-YFP at 4D 16H. White box represents the stem cell niche were cells were tracked over time. Scale bar = 20 µm. (right, top) YFP-positive cells tracked every 2 h from 4D 16H (left) to 4D 20H (right). Stem cells that were tracked are marked in blue (CEI), green (Epi/LRC), and orange (Xyl). Two Xyl cells were tracked, #1 and #2. All of these four stem cells had no measurable YFP expression at 4D 22H. (right,bottom) Quantification of YFP expression in tracked cells. c ODE model prediction of cell-specific TCX2 expression from 4D to 5D. FPKM: fragments per kilobase per million mapped reads.