Table 1.
Sociodemographic and clinical characteristics of the cohorts
| MNC | MACS | |||||
|---|---|---|---|---|---|---|
| Characteristic | MDDa (n = 186) | HCa (n = 210) | p (HC vs. MDD) | MDDa (n = 397) | HCa (n = 462) | p (HC vs. MDD) |
| Sociodemographic | ||||||
| Sex | ♀100♂86 | ♀107♂103 | 0.576b | ♀242 ♂155 | ♀273 ♂189 | 0.578b |
| Age, years | 38.66 ± 11.68 | 38.61 ± 10.40 | 0.966c | 37.31 ± 13.47 | 36.74 ± 12.72 | 0.522c |
| Questionnaires | ||||||
| HDRS | 23.60 ± 4.61 | 0.89 ± 1.27 | <0.001c | 11.98 ± 7.22 | 1.48 ± 2.22 | <0.001c |
| Childhood Trauma Questionnaire | ||||||
| CTQ sum | 47.11 ± 17.36 | 36.64 ± 9.08 | <0.001c | 47.57 ± 16.49 | 34.17 ± 9.21 | <0.001c |
| CTQ emotional neglect | 13.55 ± 5.42 | 10.62 ± 3.89 | <0.001c | 13.83 ± 5.44 | 9.15 ± 3.77 | <0.001c |
| CTQ physical neglect | 8.17 ± 3.11 | 6.91 ± 2.05 | <0.001c | 8.26 ± 3.30 | 6.49 ± 1.96 | <0.001c |
| CTQ sexual abuse | 6.44 ± 3.81 | 5.32 ± 1.17 | <0.001c | 6.54 ± 3.54 | 5.34 ± 1.50 | <0.001c |
| CTQ emotional abuse | 11.40 ± 6.44 | 7.83 ± 3.37 | <0.001c | 11.67 ± 5.27 | 7.45 ± 3.22 | <0.001c |
| CTQ physical abuse | 7.56 ± 4.07 | 5.96 ± 2.32 | <0.001c | 7.27 ± 3.49 | 5.74 ± 1.75 | <0.001c |
CTQ Childhood Trauma Questionnaire, HC healthy controls, HDRS Hamilton Depression Rating Scale, HC healthy controls, MACS Marburg-Münster Affective Disorders Cohort Study, MDD participants with major depressive disorder, MNC Münster Neuroimaging Cohort
aNumbers represent mean plus standard deviation, except for “Sex” which is noted as absolute values
bχ2-test (two-tailed)
ct-test (two-tailed)