Table 3.
ANCOVA with extracted mean FA from the significant CTQ cluster as dependent variable analyzed in the MDD patients alone with age, TIV, sex, total CTQ scores, HDRS Scores, MedIndex, comorbid diagnosis (yes vs. no), and number of hospitalizations as independent variables
| MNC | MACS | |||||
|---|---|---|---|---|---|---|
| F(1177) | p-value | Sig. | F(1382) | p-value | Sig. | |
| Age | 32.14 | <0.001 | *** | 4.49 | 0.035 | * |
| TIV | 7.08 | 0.008 | ** | 16.46 | <0.001 | *** |
| Sex | 2.10 | 0.149 | 1.85 | 0.175 | ||
| CTQ | 9.81 | 0.002 | ** | 4.53 | 0.034 | * |
| Marburg pre body coil | – | – | – | 18.58 | <0.001 | *** |
| Marburg post body coil | – | – | – | 21.13 | <0.001 | *** |
| HDRS | 0.63 | 0.428 | 0.55 | 0.459 | ||
| MedIndex | 1.76 | 0.186 | 0.07 | 0.794 | ||
| Comorbidity | 0.42 | 0.517 | 2.03 | 0.155 | ||
| Hospitalizations | 0.13 | 0.714 | 1.98 | 0.160 | ||
CTQ Childhood Trauma Questionnaire, HDRS Hamilton, MedIndex medication load index, MACS Marburg-Münster Affective Disorders Study, MDD major depressive disorder, MNC Münster Neuroimaging Cohort, TIV Total intracranial volume
***p < 0.001, **p < 0.01, *p < 0.05