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. 2019 Dec 6;9:18560. doi: 10.1038/s41598-019-54707-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The DLFEA-predicted coaptation area variation with pressure is shown in (a) for three specific sets of reference configuration geometries. (b) Shows a similar plot with variation in material coefficient 1 (see Supplement for more details) for three specific reference configurations, pressure, and other material properties. (c) is a similar plot with variation in geometry parameter (belly curve parameter, see Supplement) for two specific material properties, and pressure. These plots are generated with 1000 intermediate values in the parameter of interest. The region estimating 10% variation of the predicted coaptation area value is highlighted.