Table 2.
Laboratory parameters and their association with clinical outcome.
| Total (n = 274) |
Event (n = 97) |
No Event (n = 177) | Univariable | Multivariable | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | ||||
| Hemoglobin, mg/dl | 12.5 ± 1.7 | 12.0 ± 1.8 | 12.7 ± 1.6 | 0.796 (0.704–0.899) | <0.001 | 0.840 (0.741–0.952) | 0.006 |
| Platelet count, G/L | 233.9 ± 75.1 | 244.9 ± 84.8 | 227.8 ± 68.7 | 1.002 (1.000–1.005) | 0.053 | ||
| White blood count, G/L | 7.1 (5.7–8.7) | 7.1 (5.7–9.6) | 7.1 (5.8–8.3) | 2.044 (0.493–8.472) | 0.324 | ||
| Serum iron, μg/dl | 66.0 (46.5–95.5) | 57.0 (42.0–79.0) | 74.5 (49.0–104.3) | 0.364 (0.196–0.675) | 0.001 | ||
| Total bilirubin, mg/dl | 0.6 (0.4–0.9) | 0.6 (0.5–0.9) | 0.5 (0.4–0.9) | 1.235 (0.559–2.725) | 0.602 | ||
| Albumin, mg/dl | 40.6 ± 4.9 | 40.1 ± 5.6 | 41.0 ± 4.4 | 0.964 (0.922–1.008) | 0.105 | ||
| Lipase, U/L | 31.0 (22.0–45.0) | 32.0 (21.0–43.0) | 31.0 (22.0–46.0) | 1.136 (0.517–2.498) | 0.751 | ||
| Alkaline phosphatase, U/L | 77.0 (62.0–98.0) | 81.0 (64.5–113.5) | 75.0 (61.0–92.5) | 1.770 (0.544–5.759) | 0.343 | ||
| ASAT, U/L | 25.0 (20.0–31.3) | 24.0 (19.5–31.0) | 25.0 (21.0–32.0) | 0.413 (0.105–1.624) | 0.205 | ||
| ALAT, U/L | 22.0 (16.0–29.0) | 19.0 (14.0–26.0) | 23.0 (18.0–31.0) | 0.175 (0.064–0.482) | 0.001 | ||
| Gamma-GT, U/L | 36.0 (22.0–66.0) | 49.0 (26.5–100.5) | 33.0 (21.0–51.0) | 2.499 (1.544–4.044) | < 0.001 | 1.002 (1.001–1.003) | 0.004 |
| LDH, U/L | 215.0 (185.0–253.0) | 222.0 (185.0–273.5) | 211.0 (185.0–246.5) | 3.546 (0.536–23.473) | 0.189 | ||
| C-reactive protein, mg/dl | 0.4 (0.2–0.9) | 0.6 (0.2–1.4) | 0.4 (0.2–0.8) | 1.814 (1.236–2.663) | 0.002 | ||
| Cholesterol, mg/dl | 171.1 ± 41.4 | 163.8 ± 43.3 | 175.2 ± 39.8 | 0.992 (0.988–0.997) | 0.001 | ||
| Triglycerides, mg/dl | 113.0 (83.0–155.0) | 113.0 (89.0–158.8) | 116.0 (81.0–153.0) | 0.758 (0.269–2.139) | 0.601 | ||
| GFR, ml/min/1.73 m2 | 59.4 ± 19.9 | 52.4 ± 17.0 | 63.2 ± 20.4 | 0.977 (0.967–0.987) | <0.001 | ||
| HbA1c, % | 5.9 (5.6–6.5) | 6.1 (5.7–6.7) | 5.9 (5.6–6.5) | 2.326 (0.573–9.442) | 0.238 | ||
| NT-proBNP quartile (pg/ml) | 3.015 (1.926–4.719) | <0.001 | 2.213 (1.373–3.569) | 0.001 | |||
| 0–600, n (%) | 89 (32.5) | 20 (20.6) | 69 (38.9) | ||||
| 601–1200, n (%) | 59 (21.5) | 11 (11.3) | 48 (27.1) | ||||
| 1201–1800, n (%) | 48 (17.5) | 22 (22.7) | 26 (14.7) | ||||
| >1800, n (%) | 78 (28.5) | 44 (45.4) | 34 (19.3) | ||||
Continuous values are shown as mean ± standard deviation or median (interquartile range); ALAT - Alanin Aminotransferase, ASAT - Aspartat Aminotransferase, GFR - Glomerular Filtration Rate, GT - Glutamyl Transferase, LDH - Lactatdehydrogenase, NT-proBNP - N-terminal pro Brain Natriuretic Peptide.