Fig. 1.

Results of the multiple regression analysis between the regional gray-matter volume (GMV) and CpG 5,6 methylation. Brain region showing negative correlations between the degree of CpG 5,6 methylation and GMV in the left orbitofrontal cortex (−25, 49, −8 [BA 11]) as determined by multiple regression analysis. The statistical threshold for the contrasts was voxel-level P < 0.001 uncorrected for height and cluster-level P < 0.05 family-wise error corrected for multiple comparisons. The color bar denotes the t-statistic range. The scatter plot and dashed line show the association between the degree of CpG 5,6 methylation and the GMV in the left orbitofrontal cortex. The red squares and line represent the childhood maltreatment (CM) group, and the blue circles and line represent the Non-CM group. OXTR: oxytocin receptor gene, OFC: orbitofrontal cortex