Table 1.
Susceptibility profiles of all blaKPC-2-containing isolates.
| Antimicrobials | K. pneumoniae C1985 | E. coli C1992 | E. asburiae C2135 | |||
|---|---|---|---|---|---|---|
| MIC | Interpreted | MIC | Interpreted | MIC | Interpreted | |
| Amoxicillin/clavulanic acid | >16 | R | >16 | R | >16 | R |
| Piperacillin/tazobactam | >64 | R | >64 | R | >64 | R |
| Cefepime | 2 | S | 8 | SDD | 2 | S |
| Cefotaxime | 4 | R | 16 | R | 8 | R |
| Ceftazidime | 8 | I | 16 | R | 4 | S |
| Ceftriaxone | 16 | R | >32 | R | 32 | R |
| Ertapenem | 1 | I | 4 | R | ≤0.5 | S |
| Imipenem | 1 | S | 4 | R | 4 | R |
| Meropenem | 2 | I | 4 | R | 2 | I |
| Doripenem | 1 | S | 2 | I | ≤0.5 | S |
| Amikacin | ≤8 | S | ≤8 | S | ≤8 | S |
| Gentamicin | ≤2 | S | ≤2 | S | ≤2 | S |
| Ciprofloxacin | ≤0.06 | S | ≤0.06 | S | ≤0.06 | S |
| Levofloxacin | ≤0.06 | S | ≤0.06 | S | ≤0.06 | S |
| Netilmicin | ≤8 | S | ≤8 | S | ≤8 | S |
| Trimethoprim/sulfamethoxazole | ≤1 | S | ≤1 | S | ≤1 | S |
| Colistin | ≤1 | WT or S* | ≤1 | WT or S* | ≤1 | WT or S* |
| Tigecycline | ≤0.25 | S* | ≤0.25 | S* | 0.5 | S* |
R = resistance; I = intermediate; S = susceptible; SDD = susceptible dependent dose; WT = wild type.
*interpret following EUCAST, 2019.