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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Addict Biol. 2019 Jun 7;25(4):e12782. doi: 10.1111/adb.12782

Figure 2.

Figure 2

c-Fos expression in medial prefrontal cortex – prelimbic region (mPFC; A), nucleus accumbens core (AcbC; B) and nucleus accumbens shell (AcbSh; C) following water or 0.4N+1.0A (0.4 mg/kg nicotine + 1 g/kg alcohol, IG) in rats trained to discriminate N+A from water. Bars are mean (±SEM) c-Fos positive pixels/mm2. There was significantly more c-Fos expression in mPFC and AcbC following N+A compared to water. Representative photomicrographs appear above each figure. Scale bars = 250 µm. * - N+A treatment significantly greater than water treatment (p < 0.05).