Table 1.

Mean(±SEM) locomotor rate (beam breaks per min) for all behavioral experiments. *-indicates significant main effect of cumulative dose, p<0.05.

		N+A (mg/kg+g/kg)				Nicotine (mg/kg)				Alcohol (g/kg)
		0.1N+0.1A	0.2N+0.3A	0.4N+1.0A	0.8N+1.7A	0.1	0.2	0.4	0.8	0.1	0.3	1	1.7
Feature Positive Group
hM4D	VEH	29.25±9.44	31.25±8.37	46.83±5.75	40.91±10.59*	29.75±2.71	23.58±2.19	33.75±4.11	44.75±4.18*	22.16±0.97	21.83±1.37	20.66±1.77	22.83±1.79
	CNO	29.166±5.73	31.58±6.25	28.75±6.75	40.08±4.56*	36.25±9.23	29.75±7.05	42.5±7.78	44.5±5.47*	27.66±5.07	33.25±6.19	40.91±4.3	29±6.2
mCherry	VEH	29.78±6.82	38.64±7.38	40.07±6.39	36.92±8.07*	25.78±2.36	23.78±1.61	34.28±4.20	38.28±4.48*	23.41±1.82	24±1.97	25.28±3.46	23.42±1.52
	CNO	29.57±6.08	37.42±5.71	36.21±5.54	32.42±6.05*	26.78±3.35	26.78±2.82	41±7.03	35.64±4.82*	25.78±3.42	27.42±3.4	25.14±2.31	21.66±2.20
Feature Negative Group
hM4D	VEH	27.64±4.72	25.35±3.14	31.5±2.95	34.07±4.37	37.71±10.16	25.64±2.31	30.35±2.44	35.78±3.83*	35.71±5.22	31.28±3.22	29.64±2.55	28.5±2.48*
	CNO	22.71±2.29	24.92±2.44	35.78±1.27	32.35±3.54	23.28±3.35	43.14±3.32	44.21±7.44	35.71±3.38*	35.57±2.63	23.35±2.51	23.5±3.36	29.21±2.36*
mCherry	VEH	29.5±4.39	24.35±2.96	29.42±3.03	26.92±2.48	29.92±4.13	26.42±2.19	26.78±2.43	31.78±3.96*	31.92±4.03	25.42±3.85	26.28±2.03	27.35±2.66*
	CNO	30±2.98	24.64±2.09	27.07±2.64	23.92±2.37	27.5±3.43	28.78±3.11	27.71±2.92	25.5±1.82*	30.35±3.17	24.42±2.56	29.14±2.36	24.07±2.84*