Table 2.

Analgesic Target Clinical Failures

NK1 - substance P/tachykinin receptor antagonist

TRPV1 - noxious heat/proton/capsaicin transducer antagonist

Nav1.7 - voltage-gated sodium channel blocker/nociceptor excitability

Cav3.2 - calcium channel blocker/synaptic transmission

Kv7 - potassium channel opener/nociceptor excitability

FAAH1 - enzyme inhibitor- cannabinoid enhancer

CB1/CB2 - cannabinoid receptors agonists

α2 adrenergic receptor inhibitor

p38 - intracellular kinase inhibitor

CCR2 - chemokine antagonist