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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biol Psychiatry. 2019 Jun 29;87(1):74–81. doi: 10.1016/j.biopsych.2019.06.017

Table. 3.

New Targets in Clinical Development

NGF/TrkA reduction in nerve growth factor or its action on its receptor
Nav1.8 blockers of sodium channel expressed by nociceptors
Biased Opiate Receptor GPCRs attempt to differentiate analgesic and adverse effects of Mu receptor activation
Kappa Opiate Receptor - peripheralized agonists to avoid the central dysphoria
AT2R angiotensin 2 receptor - expressed in macrophages and contributing to immune activation of nociceptors
mPGESl reduce prostanoid synthesis
P2X purinergic receptors block activation of nociceptors by ATP
GABA subtype-selective modulators - target GABA receptors in nociceptive circuits