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How were the targets discovered (failed targets - italics)?
| Following clinical discovery of efficacy of drug |
| MOR/COX-2/VGSC/SPR |
| Following preclinical discovery of efficacy of drug |
| A2D/AT2R/KOR/5HT1/FAAH1/CB2/CB1/alpha2 |
| Preclinical discovery of pain-related mechanisms |
| NMDAR/SNRI/Cav2.2/CGRP/NGF/Nav.18/P2X/GABA/NK1/TRPV1/Kv7/Cav3.2/p38/CCR2 |
| Human genetics |
| Nav1.7 |
