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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Prog Retin Eye Res. 2019 Jul 10;73:100769. doi: 10.1016/j.preteyeres.2019.07.002

Figure 3: Somal apoptotic signaling in glaucomatous neurodegeneration.

Figure 3:

Diagram of the molecules that contribute to somal degeneration in glaucoma-relevant axonal injury. The mitogen activated protein kinase family and endoplasmic reticulum are important for pro-apoptotic signaling in glaucomatous neurodegeneration. MAPK3 kinases, DLK and LZK, activate the MAP2Ks, MKK4 and MKK7, which in turn activate the MAPKs, JNK1–3 and their canonical target JUN. The transcription factors JUN and DDIT3/CHOP lead to transcriptional changes that ultimate culminate in BAX activation and RGC apoptosis (Figure adapted from Fernandes et al., 2018).