Figure 6: The Wld^S allele prevents ocular hypertensive induced dendritic remodeling.

Retinal cells were labeled using DiO/Dil bullets in 9 month D2-Gpnmb+, wildtype DBA/2J (D2), and DBA/2J animals carrying the Wld^S allele and RGCs were subsequently selected for analysis (A). While there was a significant decrease (*) in mean dendritic field area in RGCs from wildtype D2 animals as compared to D2-Gpnmb+ animals, there was no difference between mean field area (B) or number of intersections (C, as determined by Sholl analysis) between RGCs from D2-Gpnmb+ animals and those DBA/2J animals carrying the Wld^S allele. These results demonstrate that presence of the Wld^S allele prevents ocular hypertension induced dendritic changes (Figure from Harder et al., 2017).