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. Author manuscript; available in PMC: 2020 Jun 2.
Published in final edited form as: Nat Med. 2019 Dec 2;25(12):1865–1872. doi: 10.1038/s41591-019-0667-0

Figure 3. Children single positive, multiple positive, consecutively positive and/or prolonged shedding for Enterovirus B (EV-B) on risk of islet autoimmunity.

Figure 3.

The pattern groups were the following: 1) child was negative for EV-B (reference group), 2) child had a single sample positive for EV-B, 3) child had multiple, independent, non-consecutive samples positive for EV-B, 4) child had consecutive EV-B, but with unconfirmed prolonged shedding, and 5) child had multiple and prolonged shedding of the same EV-B serotype. Consecutive positive allowed for no more than one missed monthly stool sample. Odds ratios (OR, circle) and 95% confidence intervals (CI, bars) were calculated using conditional logistic regression models with adjustment for HLA-DR-DQ genotype. All p-values were two-sided.