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. 2019 Oct 16;8(21):e013750. doi: 10.1161/JAHA.119.013750

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Demonstration of the utility of pacing during the absolute refractory period to suppress spontaneous repolarization alternans (RA) during acute ischemia (N=7 animals). (A) Alternans voltage and K_score for each animal at baseline during balloon occlusion, during triggered pacing and during baseline again after cessation of pacing. (B) Summary results for alternans voltage and K_score across all animals, during the three interventions. At baseline, during balloon occlusion, markedly elevated levels of RA are observed. When triggered pacing is initiated, a significant decrease in alternans voltage and K_score is observed. With cessation of pacing, the RA magnitude again returns to the elevated levels seen at baseline. CS indicates coronary sinus; LV, left ventricular; RV, right ventricular. *denotes statistical significance of p<0.05.