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. 2019 Oct 18;8(21):e013764. doi: 10.1161/JAHA.119.013764

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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A through E, Metabolism of PBMCs. A, Extracellular lactate production in unstimulated PBMCs (n=8). B, Representative result of the OROBOROS. C, Oxygen consumption is presented as basal respiration (basal) (n=6), proton leak after inhibition of ATP synthase (leak) (n=4), maximal oxygen consumption (max) (n=4), residual oxygen consumption or non‐mitochondrial oxygen consumption (rox) (n=6). D and E, Absolute and relative oxygen consumption reserve (n=4). Data before (white) and after intervention (grey) are shown in boxplots (median±interquartile range). Whiskers represent 90% CI. *P<0.05.