Figure 3.

Glycolysis. Forrest plot of HK1 (A) and bubble plot showing meta‐regression analysis of HK1 expression at mRNA level with the duration of RV pressure load (B). Forrest plots of HK2 (C) expression at mRNA level and glycolytic flux measured with Seahorse or Langendorf (D). Data are presented as Hedges’ g. Combined Hedges’ g are presented as squares: gray representing Hedges’ g of a specific model, black representing Hedges’ g of all included studies. Bars represent 95% CI. Bubble size represents relative study precision, calculation based on SD. Black line represents regression line, gray lines represents 95% CI. = indicates not statistically significantly affected; ↓, decreased; 95% CI, cardiac index; CO, cardiac output; FHR, fawn hooded rats; HK, hexokinase; i², level of heterogeneity; MCT, ; n, number of included animals; PAB, pulmonary artery banding; PH, pulmonary hypertension; RVEF, right ventricular ejection fraction; TAPSE, tricuspid annular plane systolic movement; X, not included in meta‐analysis.