Table 3.
Subgroup Analysis of Clinical Outcomes in ABAO Patients
| Outcome variables | Subgroups | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tandem lesion | ICAS | ASITN/SIR collateral system | Prior use of intravenous tPA | |||||||||
| Yes (n = 25) | No (n = 162) | P value | Yes (n = 117) | No (n = 70) | P value | Grade 0–2 (n = 165) | Grade 3–4 (n = 22) | P value | Yes (n = 36) | No (n = 151) | P value | |
| Successful recanalization (mTICI 2b-3) | 15 (60.0) | 143 (88.3) | < 0.01 | 100 (85.5) | 58 (82.9) | 0.63 | 137 (83.0) | 21 (95.5) | 0.21 | 30 (83.3) | 128 (84.8) | 0.80 |
| Complete recanalization (mTICI 3) | 13 (52.0) | 113 (69.8) | 0.11 | 77 (65.8) | 49 (70.0) | 0.55 | 108 (65.5) | 18 (81.8) | 0.15 | 26 (72.2) | 100 (66.2) | 0.49 |
| Hemorrhagic transformation within 24 h | 4 (16.0) | 25 (15.4) | > 0.99 | 16 (13.7) | 13 (18.6) | 0.37 | 26 (15.8) | 3 (13.6) | > 0.99 | 7 (19.4) | 22 (14.6) | 0.45 |
| SICH (ECASS III definition) within 24 h | 2 (8.0) | 6 (3.7) | 0.29 | 4 (3.4) | 4 (5.7) | 0.48 | 7 (4.2) | 1 (4.6) | > 0.99 | 1 (2.8) | 7 (4.6) | > 0.99 |
| Functional independence (mRS 0–2) at 90 days | 7 (28.0) | 61 (37.7) | 0.38 | 43 (36.8) | 25 (35.7) | 0.89 | 55 (33.3) | 13 (59.1) | 0.03 | 15 (41.7) | 53 (35.1) | 0.46 |
| Favorable outcome (mRS 0–3) at 90 days | 8 (32.0) | 84 (51.9) | 0.07 | 62 (53.0) | 30 (42.9) | 0.18 | 75 (45.5) | 17 (77.3) | 0.01 | 19 (52.8) | 73 (48.3) | 0.63 |
| Mortality at 90 days | 11 (44.0) | 27 (16.7) | 0.01 | 20 (17.1) | 18 (25.7) | 0.16 | 36 (21.8) | 2 (9.1) | 0.26 | 6 (16.7) | 32 (21.2) | 0.65 |
Abbreviations: ASITN/SIR American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology, ECASS European Cooperative Acute Stroke Study, ICAS intracranial atherosclerotic stenosis, mRS modified Rankin Scale, mTICI modified Thrombolysis in Cerebral Infarction, SICH symptomatic intracerebral hemorrhage, tPA tissue Plasminogen Activator