Table 4.
Most significant gene expression associated with RFI and their related metabolic pathway
| Symbol | Effect | p-value | Dataseta | Pathway |
|---|---|---|---|---|
| NREP-Neuronal Regeneration Related Protein | −0.21 | 4.66E-06 | BM | MECP2 and Associated Rett Syndrome |
| NAALADL1- N-Acetylated Alpha-Linked Acidic Dipeptidase Like 1 | 0.33 | 1.33E-05 | HB | – |
| NCOA4- Nuclear Receptor Coactivator 4 | 0.18 | 1.49E-05 | SL | Pathways in cancer, Thyroid cancer |
| CD8B- CD8b Molecule | 0.34 | 1.97E-05 | HB | T-Cell Receptor and Co-stimulatory Signaling, Innate Immune System |
| DHCR7–7-Dehydrocholesterol Reductase | −0.29 | 2.32E-05 | BM | Regulation of cholesterol biosynthesis by SREBP (SREBF), cholesterol biosynthesis I |
| ENSBTAG00000039588 | 0.39 | 3.81E-05 | HB | – |
| SYNE2- Spectrin Repeat Containing Nuclear Envelope Protein 2 | 0.11 | 4.01E-05 | BM | Meiosis, Ovarian Infertility Genes |
| OLFML1- Olfactomedin Like 1 | −0.51 | 4.56E-05 | BM | – |
| ANGPTL2- Angiopoietin Like 2 | −0.27 | 5.93E-05 | BM | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways |
| ACADSB- Acyl-CoA Dehydrogenase Short/Branched Chain | −0.29 | 6.29E-05 | BL | Fatty acid degradation, Valine, leucine and isoleucine degradation, Metabolic pathways, Fatty acid metabolism |
| DDIT3- DNA Damage Inducible Transcript 3 | −0.22 | 7.26E-05 | BM | MAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer |
| TDRP- Testis Development Related Protein | −0.45 | 1.21E-04 | HL | – |
| CCDC38- Coiled-Coil Domain Containing 38 | 0.68 | 1.67E-04 | BL | – |
| AIM1- Absent in melanoma 1 | 0.15 | 1.91E-04 | BL | Fatty acid degradation, alpha-Linolenic acid metabolism, Metabolic pathways, Biosynthesis of secondary metabolites, Fatty acid metabolism |
| PLA2G16- Phospholipase A2 Group XVI | 0.18 | 2.32E-04 | HL | Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, Linoleic acid metabolism, alpha-Linolenic acid metabolism, Metabolic pathways, Ras signaling pathway, Regulation of lipolysis in adipocytes |
| TMEM135- Transmembrane Protein 135 | −0.21 | 2.50E-04 | BM | – |
| CENPM- Centromere Protein M | 0.45 | 2.82E-04 | SL | Chromosome Maintenance, Signaling by Rho GTPases |
| EIF2A- Eukaryotic Translation Initiation Factor 2A | 0.16 | 2.83E-04 | BL | RNA transport, Protein processing in endoplasmic reticulum |
| SQLE- Squalene Epoxidas | −0.45 | 2.84E-04 | BM | Steroid biosynthesis, Metabolic pathways, Biosynthesis of antibiotics |
| GSTT3- Glutathione S-Transferase Theta 3 | 0.27 | 2.91E-04 | BL | Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Chemical carcinogenesis |
| HMGCS1–3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 | −0.24 | 2.94E-04 | BM | Synthesis and degradation of ketone bodies, Valine, leucine and isoleucine degradation, Butanoate metabolism, Terpenoid backbone biosynthesis, Metabolic pathways, Biosynthesis of antibiotics |
| GHDC- GH3 Domain Containing | 0.17 | 3.59E-04 | HL | Innate Immune System |
| EIF3H- Eukaryotic Translation Initiation Factor 3 Subunit H | 0.10 | 3.62E-04 | BL | RNA transport, Measles |
| GPATCH11- G-Patch Domain Containing 11 | 0.33 | 4.14E-04 | SL | – |
| NET1- Neuroepithelial Cell Transforming 1 | −0.14 | 4.19E-04 | HL | p75 NTR receptor-mediated signaling, fMLP Pathway |
| BCKDHB- Branched Chain Keto Acid Dehydrogenase E1 Subunit Beta | 0.10 | 4.32E-04 | SL | Valine, leucine and isoleucine degradation, Metabolic pathways, Biosynthesis of antibiotics |
| DNER- Delta/Notch Like EGF Repeat Containing | −1.13 | 4.33E-04 | BM | Signaling by NOTCH1 and NOTCH2 Activation, Transmission of Signal to the Nucleus |
| ALDH5A1- Aldehyde Dehydrogenase 5 Family Member A1 | 0.14 | 4.81E-04 | BL | Alanine, aspartate and glutamate metabolism, Butanoate metabolism, Metabolic pathways |
| ROBO2- Roundabout Guidance Receptor 2 | 0.49 | 5.03E-04 | BL | Axon guidance |
| GSTM2- Glutathione S-Transferase Mu 2 | 0.61 | 5.51E-04 | BL | Glutathione metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Chemical carcinogenesis |
| PRICKLE1-Prickle Planar Cell Polarity Protein 1 | −0.31 | 5.62E-04 | BL | Wnt signaling pathway |
| ENSBTAG00000040281 | 0.59 | 6.02E-04 | HB | – |
| IFI47- Interferon Gamma Inducible Protein 4 | 0.88 | 6.02E-04 | SL | TNF signaling pathway |
| ENSBTAG00000002786 | −1.10 | 6.42E-04 | SL | – |
| RBP1- Retinol Binding Protein 1 | 0.55 | 7.01E-04 | HB | Nicotinate and nicotinamide metabolism, Metabolic pathways |
| UBE2D2- Ubiquitin Conjugating Enzyme E2 D2 | 0.10 | 7.21E-04 | SL | Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum |
| ENSBTAG00000001489 | −0.18 | 7.24E-04 | SB | Phagosome, Gap junction |
| GDPGP1- GDP-D-Glucose Phosphorylase 1 | 0.32 | 7.40E-04 | HB | – |
| ITGB4- Integrin Subunit Beta 4 | 0.34 | 8.59E-04 | HL | PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Regulation of actin cytoskeleton, Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
| URI1- URI1, Prefoldin Like Chaperone | 0.19 | 9.32E-04 | SL | Translational Control, Apoptosis and Autophagy |
aBM: bulls_muscle, HB: H-heifers_blood, SL: H-steers_blood, BL: A-bulls_liver, HL: H-heifers_liver