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. 2019 Dec 7;20:591. doi: 10.1186/s12891-019-2977-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The effects of TNF-α and MTX on OA FLS and RA FLS. a-b The effects of TNF-α and MTX on the proliferation of OA FLS and RA FLS. c The effects of TNF-α and MTX on the migration of OA FLS and RA FLS. d The effects of MTX on apoptosis of OA FLS and RA FLS. e-f The effects of TNF-α and MTX on the mRNA expression of pro-inflammatory genes in OA FLS and RA FLS. e-f The effects of TNF-α and MTX on the protein expression of IL-1 and IL-6 in OA FLS and RA FLS. i The effects of TNF-α and MTX on IL-6 production from OA FLS and RA FLS. Each bar in the figure represents the mean ± SEM of triplicates. Scale bar=500 μm. *P < 0.05 and ** P < 0.01