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. 2019 Dec 2;15:3327–3340. doi: 10.2147/NDT.S228417

Figure 4.

Figure 4

Effects of CIG on MBP expression and the number of mature oligodendrocytes in the corpus callosum of MCAO rats.

Notes: (A) Representative images of MBP immunohistochemistry. Scale bar = 500 µm. (B) Western blot images of MBP expression. (C) Quantitative analysis of MBP expression from the Western blot images. β-Actin served as an internal loading control. (D) Representative images of APC-labeled mature oligodendrocytes. Scale bar = 1000 µm. (E) Quantitative analysis of the number of APC-positive cells. Data are expressed as mean ± SEM, n = 3 each group. #P<0.05, ###P<0.001, model group vs sham control group; *P<0.05, ***P<0.001, drug-treated groups vs model group.

Abbreviations: CIG, cornel iridoid glycoside; MBP, myelin basic protein; MCAO, middle cerebral artery occlusion; SEM, standard error of mean; CIG-L, CIG 60 mg/kg; CIG-H, CIG 120 mg/kg; EGB, the extract of Ginkgo biloba 12 mg/kg.