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. 2019 Nov 11;12(11):dmm040584. doi: 10.1242/dmm.040584

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Chemical structures of 20 drug repurposing candidates discovered in a worm pmm-2 bortezomib chemical modifier screen. Fully capitalized compounds are active in the human PMM2 enzyme activity assay performed in R141H/F119L PMM2-CDG fibroblasts as described in Materials and Methods. Underlined compounds are active in at least one of three yeast PMM2-CDG models described by Lao et al. (2019). The yellow box indicates compounds that are active in the Keap1-Nrf2 cellular reporter assay described in Materials and Methods. The purple box indicates compounds that are catecholamines. The grey box indicates structural singletons with nonselective antioxidant properties. (1) pyrogallin, (2) fiseti,. (3) purpurogallin-4-carboxylic acid, (4) rhamnetin, (5) quercetin tetramethyl ether, (6) gossypetin, (7) ellagic acid, (8) hieracin (tricetin), (9) baicalein, (10) koparin, (11) epicatechin monogallate, (12) theaflavin monogallate, (13) 3-methoxycatechol, (14) 2,3,4-trihydroxy-4-methoxybenzophenone, (15) 3,4-didesmethyl-5-deshydroxy-3-ethoxyschleroin, (16) levodopa, (17) ethylnorepinephrine, (18) dobutamine, (19) amidol, (20) edaravone.