. 2019 Dec 3;12:2549–2557. doi: 10.2147/DMSO.S190356

Table 2.

Ongoing Clinical Trials Assessing Dapagliflozin in Patients with Heart Failure or Chronic Kidney Disease

Study Name	Treatment Arms	Duration	Population	Primary Outcome
DETERMINE-reduced - Dapagliflozin Effect on Exercise Capacity Using a 6 min Walk Test in Patients With Heart Failure With Reduced Ejection Fraction; NCT03877237 ⁴⁰	Dapagliflozin, placebo	16 weeks	300 patients with HFrEF	Change from baseline in 6 min walking distance
Effect of Dapagliflozin Plus Low Dose Pioglitazone on Hospitalization Rate in Patients With HF and HFpEF; NCT03794518 ⁴¹	Dapagliflozin plus pioglitazone, placebo	3 years	648 patients with T2DM and HFpEF	Time to first hospitalization for heart failure after starting intervention
Dapagliflozin Evaluation to Improve the LIVEs of Patients With PReserved Ejection Fraction Heart Failure. (DELIVER); NCT03619213 ⁴²	Dapagliflozin, placebo	33 months	4700 patients with or without T2DM and HFpEF	Time to the first occurrence of any of the components of the composite outcome: CV death, hospitalization for HF, or urgent HF visit
DETERMINE-preserved -Dapagliflozin Effect on Exercise Capacity Using a 6 min Walk Test in Patients With Heart Failure With Preserved Ejection Fraction; NCT03877224 ⁴³	Dapagliflozin, placebo	16 weeks	400 patients with HFpEF	Change from baseline in 6 min walking distance
Dapagliflozin in PRESERVED Ejection Fraction Heart Failure (PRESERVED-HF); NCT03030235 ⁴⁴	Dapagliflozin, placebo	12 weeks	320 patients with HFpEF	Change from baseline in NTproBNP
Impact of Dapagliflozin on DIAstolic Dysfunction in Type 2 Diabetic Patients; NCT02751398 ⁴⁵	Dapagliflozin, placebo	24 weeks	60 patients with T2DM and diastolic dysfunction	Subclinical diastolic dysfunction assessed by supine bicycle diastolic stress echocardiography
A Study to Evaluate the Effect of Dapagliflozin on Renal Outcomes and Cardiovascular Mortality in Patients With Chronic Kidney Disease (Dapa-CKD); NCT03036150 ⁴⁶	Dapagliflozin, placebo	4 years	4000 patients with or without T2DM and CKD	Time to the first occurrence of any of the components of the composite outcome: ≥50% sustained decline in eGFR or reaching ESRD or CV death or renal death

Abbreviations: CKD, chronic kidney disease; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; mo, months; NTproBNP, N-terminal pro b-type natriuretic peptide; T2DM, type 2 diabetes mellitus.