2q4 arm received intravitreal aflibercept injection (IAI) every 4 weeks from baseline to week 100, while 2q8 am received IAI every 4 weeks from baseline to week 16 (5 injections) followed by dosing every 8 weeks through week 100. The error bars indicate the standard errors of the mean. A, Mean change in best corrected visual acuity (ETDRS letters) from baseline through week 100 in 2q4 and 2q8 arms. B, Central macular mean ellipsoid zone (EZ) to retinal pigment epithelium (RPE) thickness. C, The area coverage of EZ-RPE thickness < 20 μm. D, Actual central macular mean retinal tissue thickness. E, Central macular retinal fluid index. F, Central macular subretinal fluid volume.