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. Author manuscript; available in PMC: 2020 Dec 15.
Published in final edited form as: Int J Pharm. 2019 Oct 11;572:118762. doi: 10.1016/j.ijpharm.2019.118762

Figure 4.

Figure 4.

Effects of trypsin digestion on the cellular uptake of EVs following gefitinib treatment. (a) SDS-PAGE analysis of FITC-dextran-loaded EVs before and after treatment with trypsin for 30 min at 37 °C. (b) Particle size distribution of FITC-dextran-loaded EVs before and after treatment with trypsin. (c) Table summarizing the average sizes of EVs. Data are presented as the mean (± SD) of three measurements. (d) Relative cellular uptake of FITC-dextran-loaded EVs with or without trypsin treatment in HCC827 cells in the presence or absence of gefitinib (25 and 50 nM) for 24 h at 37 °C using a flow cytometer. The data are the averages (± SD) of three experiments. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.